You can also send the results with the single calculated field (right click anywhere in the result columns) to the "Clean and Transform" and perform calculations on the calculated fields there. After adding the calculated fields you can save that and later run or schedule as needed as it will still contain the SQL.
So depending on the preferred output, level, stacking and complexity of the calculations you can:
-use subqueries, maybe even adding subqueries in subqueries in the SQL statement
-develop the SQL with just the first step calculations and send the results to:Pivot, Dimensional View or Clean and Transform, to do further calculation on calculations.
-if the first step calculation is something you might use as basis for different reports you can think of creating a local Toad View and use that view as table in those reports.
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